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Papers

2020
Morgan, J. L., & Lichtman, J. W. (2020). An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus. Neuron, 106(3). doi: 10.1016/j.neuron.2020.02.001
 
2019
 
Zonouzi M, Berger D, Jokhi V, Kedaigle A, Lichtman J, Arlotta P. Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex. Cell Rep. 2019 Jun 4;27(10):2799-2808.e3. doi: 10.1016/j.celrep.2019.05.018. PubMed PMID: 31167127.
 
Baena V, Schalek RL, Lichtman JW, Terasaki M. Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM). Methods Cell Biol.2019;152:41-67. doi: 10.1016/bs.mcb.2019.04.004. Epub 2019 Jun 8. PubMed PMID: 31326026.
 
Leckenby JI, Chacon MA, Grobbelaar AO, Lichtman JW. Imaging Peripheral Nerve Regeneration: A New Technique for 3D Visualization of Axonal Behavior. J Surg Res.2019 Oct;242:207-213. doi: 10.1016/j.jss.2019.04.046. Epub 2019 May 11. PubMed PMID: 31085369.
 
Leckenby JI, Chacon MA, Rolfe K, Lichtman JW, Grobbelaar AO. Development of the interscutularis model as an outcome measure for facial nerve surgery. Ann Anat. 2019 May;223:127-135. doi: 10.1016/j.aanat.2019.03.001. Epub 2019 Mar 22. PubMed PMID: 30910682.
 
 

Fang T, Lu X, Berger D, Gmeiner C, Cho J, Schalek R, Ploegh H, Lichtman J. Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure. Nat Methods. 2018 Dec;15(12):1029-1032. doi: 10.1038/s41592-018-0177-x. Epub 2018 Nov 5. PubMed PMID: 30397326; PubMed Central PMCID: PMC6405223.

Berger DR, Seung HS, Lichtman JW. VAST (Volume Annotation and Segmentation Tool): Efficient Manual and Semi-Automatic Labeling of Large 3D Image Stacks. Front Neural Circuits. 2018;12:88. Published 2018 Oct 16. doi:10.3389/fncir.2018.00088

Takesian AE, Bogart LJ, Lichtman JW, Hensch TK. Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018;21(2):218-227.
 

2017

Zhang H, Glenn DR, Schalek R, Lichtman JK, Walsworth RL. 2016. Efficiency of Cathodoluminescence Emmision by Nitrogen-Vacancy Color Centers in Nanodiamond. arXiv:1602.00410.
 
Morgan, J. L., & Lichtman, J. W. (2017). Digital tissue and what it may reveal about the brain. BMC Biology (in press)
 
Sheu SH, Tapia JC, Tsuriel S, Lichtman JW. Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice. Elife. 2017;6:e23193. Published 2017 Feb 3. doi:10.7554/eLife.23193
 
Vishwanathan A, Daie K, Ramirez AD, Lichtman JW, Aksay ERF, Seung HS. Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator. Curr Biol. 2017;27(14):2137-2147.e3.
 
2016
 
Morgan JL, Berger DR, Wetzel AW, Lichtman JW. The fuzzy logic of network connectivity in mouse visual thalamus. Cell. 2016;165(1):192-206. doi:10.1016/j.cell.2016.02.033.
PMCID: PMC4808248
 
Swanson LW and Lichtman JW. 2016. From Cajal to Connectome and Beyoond. Annu. Rev. Neurosci., 2016. 39:197-216, doi: 10.1146/annurev-neuro-0717140033954. PMID: 27442070
 
Gonda F, Kaynig V, Thouis R, Haehn D, Lichtman JW, Parag T, Pfister H. (2016). ICON: An interactive approach to train deep neural networks for segmentation of neuronal structures. Submitted Oct. 27, 2016
 
2015
 
Saturated Reconstruction of a Volume of Neocortex.
Kasthuri N, Hayworth KJ, Berger DR, Schalek RL, Conchello JA, Knowles-Barley S, Lee D, Vázquez-Reina A, Kaynig V, Jones TR, Roberts M, Morgan JL, Tapia JC, Seung HS, Roncal WG, Vogelstein JT, Burns R, Sussman DL, Priebe CE, Pfister H, Lichtman JW. Cell. 2015 Jul 30;162(3):648-61. doi: 10.1016/j.cell.2015.06.054. PMID: 26232230
 
Clarifying tissue Clearing
Richardson DS, Lichtman JW.Cell. 2015 Jul 16;162(2):246-57. doi: 10.1016/j.cell.2015.06.067. Review. PMID: 26186186

Multispectral labeling technique to map many neighboring axonal projections in the same tissue.
Tsuriel S, Gudes S, Draft RW, Binshtok AM, Lichtman JW.
Nat Methods. 2015 Apr 27. doi: 10.1038/nmeth.3367. [Epub ahead of print] PMID: 25915122
 
Hayworth KJ, Xu CS, Lu Z, Knott GW, Fetter RD, Tapia JC, Lichtman JW, Hess HF.
Nat Methods. 2015 Apr;12(4):319-22. doi: 10.1038/nmeth.3292. Epub 2015 Feb 16. PMID: 25686390
 
Eberle AL, Mikula S, Schalek R, Lichtman JW, Tate ML, Zeidler D.
J Microsc. 2015 Jan 27. doi: 10.1111/jmi.12224. [Epub ahead of print] PMID: 25627873
 
2014
 
The big data challenges of connectomics.
Lichtman JW, Pfister H, Shavit N. Neurosci. 2014 Nov;17(11):1448-54. doi: 10.1038/nn.3837. Epub 2014 Oct 28. Review. PMID: 25349911
 
Imaging ATUM ultrathin section libraries with WaferMapper: a multi-scale approach to EM reconstruction of neural circuits.
Hayworth KJ, Morgan JL, Schalek R, Berger DR, Hildebrand DG, Lichtman JW. Front Neural Circuits. 2014 Jun 27;8:68. doi: 10.3389/fncir.2014.00068. eCollection 2014.
PMID: 25018701

Exploring the connectome: petascale volume visualization of microscopy data streams.
Beyer J, Hadwiger M, Al-Awami A, Jeong WK, Kasthuri N, Lichtman JW, Pfister H. IEEE Comput Graph Appl. 2013 Jul-Aug;33(4):50-61. doi: 10.1109/MCG.2013.55.
PMID: 24808059
 
Terminal Schwann cells participate in neuromuscular synapse remodeling during reinnervation following nerve injury.
Kang H, Tian L, Mikesh M, Lichtman JW, Thompson WJ. J Neurosci. 2014 Apr 30;34(18):6323-33. doi: 10.1523/JNEUROSCI.4673-13.2014. PMID: 24790203
 
Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling.
Shvartsman D, Storrie-White H, Lee K, Kearney C, Brudno Y, Ho N, Cezar C, McCann C, Anderson E, Koullias J, Tapia JC, Vandenburgh H, Lichtman JW, Mooney DJ.
Mol Ther. 2014 Jul;22(7):1243-53. doi: 10.1038/mt.2014.76. Epub 2014 Apr 28.
PMID: 24769910
 
Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex.
Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. Science. 2014 Apr 18;344(6181):319-24. doi: 10.1126/science.1249766. PMID: 24744380

Silicon-vacancy color centers in nanodiamonds: cathodoluminescence imaging markers in the near infrared.
Zhang H, Aharonovich I, Glenn DR, Schalek R, Magyar AP, Lichtman JW, Hu EL, Walsworth RL. Small. 2014 May 28;10(10):1908-13. doi: 10.1002/smll.201303582. Epub 2014 Mar 4. No abstract available. PMID: 24596272

2013

Motor axon regeneration and muscle reinnervation in young adult and aged animals.
Kang H, Lichtman JW. J Neurosci. 2013 Dec 11;33(50):19480-91. doi: 10.1523/JNEUROSCI.4067-13.2013. PMID: 24336714

ConnectomeExplorer: query-guided visual analysis of large volumetric neuroscience data.
Beyer J, Al-Awami A, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. IEEE Trans Vis Comput Graph. 2013 Dec;19(12):2868-77. doi: 10.1109/TVCG.2013.142. PMID: 24051854 

Developmental bias in cleavage-stage mouse blastomeres.
Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K. Curr Biol. 2013 Jan 7;23(1):21-31.
PMID: 23177476 | PDF

Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs.
Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM.
Cell. 2013 Jul 18;154(2):285-96.
PMID: 23870120 |  PDF

Improved tools for the Brainbow toolbox.
Cai D, Cohen KB, Luo T, Lichtman JW, Sanes JR.
Nat Methods. 2013 Jun;10(6):540-7.
PMID: 23866336 |  PDF
 
Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish.
Pan YA, Freundlich T, Weissman TA, Schoppik D, Wang XC, Zimmerman S, Ciruna B, Sanes JR, Lichtman JW, Schier AF.
Development. 2013 Jul;140(13):2835-46.
PMID: 23757414 |  PDF
 
Why not connectomics?
Morgan JL, Lichtman JW.
Nat Methods. 2013 Jun;10(6):494-500.
PMID: 23722208 |  PDF
 
2012
 
Correlative light and electron microscopy using cathodoluminescence from nanoparticles with distinguishable colours.
Glenn DR, Zhang H, Kasthuri N, Schalek R, Lo PK, Trifonov AS, Park H, Lichtman JW, Walsworth RL.
Sci Rep. 2012;2:865.
PMID: 23155483 | PDF
In vivo imaging of the developing neuromuscular junction in neonatal mice.
Turney SG, Walsh MK, Lichtman JW.
Cold Spring Harb Protoc. 2012 Nov 1;2012(11):1166-76.
PMID: 23118362 | PDF
 
Agrin and synaptic laminin are required to maintain adult neuromuscular junctions.
Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR.
PLoS One. 2012;7(10):e46663.
PMID: 23056392 | PDF
 
Reversing the outcome of synapse elimination at developing neuromuscular junctions in vivo: evidence for synaptic competition and its mechanism.
Turney SG, Lichtman JW.
PLoS Biol. 2012;10(6):e1001352.
PMID: 22745601 | PDF
 
Pervasive synaptic branch removal in the mammalian neuromuscular system at birth.
Tapia JC, Wylie JD, Kasthuri N, Hayworth KJ, Schalek R, Berger DR, Guatimosim C, Seung HS, Lichtman JW.
Neuron. 2012 Jun 7;74(5):816-29. doi: 10.1016/j.neuron.2012.04.017.
PMID: 22681687 | PDF
 
Shared resistance to aging and ALS in neuromuscular junctions of specific muscles.
Valdez G, Tapia JC, Lichtman JW, Fox MA, Sanes JR.
PLoS One. 2012;7(4):e34640.
PMID: 22485182 | PDF

High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy.
Tapia JC, Kasthuri N, Hayworth KJ, Schalek R, Lichtman JW, Smith SJ, Buchanan J.
Nat Protoc. 2012 Jan 12;7(2):193-206.
PMID: 22240582 | PDF

Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers. Chakkalakal JV, Kuang S, Buffelli M, Lichtman JW, Sanes JR.
Genesis. 2012 Jan;50(1):50-8.
PMID: 21898764 | PDF
 
2011
 
The big and the small: challenges of imaging the brain’s circuits.
Lichtman JW, Denk W.
Science. 2011 Nov 4;334(6056):618-23.
PMID: 22053041 | PDF

Spatial constraints dictate glial territories at murine neuromuscular junctions.
Brill MS, Lichtman JW, Thompson W, Zuo Y, Misgeld T.
J Cell Biol. 2011 Oct 17;195(2):293-305.
PMID: 22006952 | PDF

Generating and imaging multicolor Brainbow mice.
Weissman TA, Sanes JR, Lichtman JW, Livet J.
Cold Spring Harb Protoc. 2011 Jul 1;2011(7):763-9.
PMID: 21724826 | PDF

Generation and imaging of Brainbow mice.
Weissman TA, Sanes JR, Lichtman JW, Livet J.
Cold Spring Harb Protoc. 2011 Jul 1;2011(7):851-6.
PMID: 21724817 | PDF

Delayed synapse elimination in mouse levator palpebrae superioris muscle.
Fox MA, Tapia JC, Kasthuri N, Lichtman JW.
J Comp Neurol. 2011 Oct 15;519(15):2907-21.
PMID: 21681746 | PDF

Multicolor Brainbow imaging in zebrafish.
Pan YA, Livet J, Sanes JR, Lichtman JW, Schier AF.
Cold Spring Harb Protoc. 2011 Jan 1;2011(1):pdb.prot5546.
PMID: 21205846 | PDF

2010

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise.
Valdez G, Tapia JC, Kang H, Clemenson GD Jr, Gage FH, Lichtman JW, Sanes JR.
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14863-8.
PMID: 20679195 | PDF

Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria. Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D.
J Biol Chem. 2010 Aug 27;285(35):27411-7.
PMID: 20551319 | PDF

Ballistic delivery of dyes for structural and functional studies of the nervous system.
Gan WB, Grutzendler J, Wong RO, Lichtman JW.
Cold Spring Harb Protoc. 2009 Apr;2009(4):pdb.prot5202.
PMID: 20147144 | PDF

Neurocartography.
Kasthuri N, Lichtman JW.
Neuropsychopharmacology. 2010 Jan;35(1):342-3.
PMID: 20010709 | PDF

Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors.
Borselli C, Storrie H, Benesch-Lee F, Shvartsman D, Cezar C, Lichtman JW, Vandenburgh HH, Mooney DJ.
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3287-92.
PMID: 19966309 | PDF

2009
 
Controlling the orientation and synaptic differentiation of myotubes with micropatterned substrates.
Gingras J, Rioux RM, Cuvelier D, Geisse NA, Lichtman JW, Whitesides GM, Mahadevan L, Sanes JR.
Biophys J. 2009 Nov 18;97(10):2771-9.
PMID: 19917231 | PDF

Super-resolution laser scanning microscopy through spatiotemporal modulation.
Lu J, Min W, Conchello JA, Xie XS, Lichtman JW.
Nano Lett. 2009 Nov;9(11):3883-9..
PMID: 19743870 | PDF

It’s lonely at the top: winning climbing fibers ascend dendrites solo.
Draft RW, Lichtman JW.
Neuron. 2009 Jul 16;63(1):6-8.
PMID: 19607787 | PDF

Semi-automated reconstruction of neural processes from large numbers of fluorescence images.
Lu J, Fiala JC, Lichtman JW.
PLoS One. 2009 May 21;4(5):e5655.
PMID: 19479070 | PDF

The interscutularis muscle connectome.
Lu J, Tapia JC, White OL, Lichtman JW.
PLoS Biol. 2009 Feb 10;7(2):e32. doi: 10.1371/journal.pbio.1000032. Erratum in: PLoS Biol. 2009 Apr;7(4):e1000108.
PMID: 19209956 | PDF

2008
 
Chapter 11: Imaging fluorescent mice in vivo using confocal microscopy.
Turney SG, Lichtman JW.
Methods Cell Biol. 2008;89:309-27.
PMID: 19118680 | PDF

Seeing circuits assemble.
Lichtman JW, Smith SJ.
Neuron. 2008 Nov 6;60(3):441-8.
PMID: 18995818 | PDF

Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants.
Kerschensteiner M, Reuter MS, Lichtman JW, Misgeld T.
Nat Protoc. 2008;3(10):1645-53.
PMID: 18833201 | PDF

Ome sweet ome: what can the genome tell us about the connectome?
Lichtman JW, Sanes JR.
Curr Opin Neurobiol. 2008 Jun;18(3):346-53.
PMID: 18801435 | PDF

Lysosomal activity associated with developmental axon pruning.
Song JW, Misgeld T, Kang H, Knecht S, Lu J, Cao Y, Cotman SL, Bishop DL, Lichtman JW.
J Neurosci. 2008 Sep 3;28(36):8993-9001.
PMID: 18768693 | PDF

Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo.
McCann CM, Tapia JC, Kim H, Coggan JS, Lichtman JW.
Nat Neurosci. 2008 Jul;11(7):807-15.
PMID: 18568021 | PDF

A technicolour approach to the connectome.
Lichtman JW, Livet J, Sanes JR.
Nat Rev Neurosci. 2008 Jun;9(6):417-22.
PMID: 18446160 | PDF

Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific.
Schubert T, Kerschensteiner D, Eggers ED, Misgeld T, Kerschensteiner M, Lichtman JW, Lukasiewicz PD, Wong RO.
J Neurophysiol. 2008 Jul;100(1):304-16.
PMID: 18436633 | PDF

In vivo imaging of presynaptic terminals and postsynaptic sites in the mouse submandibular ganglion.
McCann CM, Lichtman JW.
Dev Neurobiol. 2008 May;68(6):760-70.
PMID: 18383540 | PDF

2007
 
Imaging the neuromuscular junction over the past centuries.
Lu J, Lichtman JW.
Sheng Li Xue Bao. 2007 Dec 25;59(6):683-96.
PMID: 18157463 | PDF

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.
Livet J, Weissman TA, Kang H, Draft RW, Lu J, Bennis RA, Sanes JR, Lichtman JW.
Nature. 2007 Nov 1;450(7166):56-62.
PMID: 17972876 | PDF

Imaging axonal transport of mitochondria in vivo.
Misgeld T, Kerschensteiner M, Bareyre FM, Burgess RW, Lichtman JW.
Nat Methods. 2007 Jul;4(7):559-61.
PMID: 17558414 | PDF

Rapid synapse elimination after postsynaptic protein synthesis inhibition in vivo.
McCann CM, Nguyen QT, Santo Neto H, Lichtman JW.
J Neurosci. 2007 May 30;27(22):6064-7.
PMID: 17537978 | PDF

The rise of the ‘projectome’.
Kasthuri N, Lichtman JW.
Nat Methods. 2007 Apr;4(4):307-8. Erratum in: Nat Methods. 2007 Jul;4(7):595.
PMID: 17396125 | PDF

2006
 
Translational neuroscience during the Second World War.
Lichtman JW, Sanes JR.
J Exp Biol. 2006 Sep;209(Pt 18):3485-7.
PMID: 16943488 | PDF

Repulsive force based snake model to segment and track neuronal axons in 3D microscopy image stacks.
Cai H, Xu X, Lu J, Lichtman JW, Yung SP, Wong ST.
Neuroimage. 2006 Oct 1;32(4):1608-20.
PMID: 16861006 | PDF

2005
 
Optical sectioning microscopy.
Conchello JA, Lichtman JW.
Nat Methods. 2005 Dec;2(12):920-31.
PMID: 16299477 | PDF

Fluorescence microscopy.
Lichtman JW, Conchello JA.
Nat Methods. 2005 Dec;2(12):910-9.
PMID: 16299476 | PDF

A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis.
Schaefer AM, Sanes JR, Lichtman JW.
J Comp Neurol. 2005 Sep 26;490(3):209-19.
PMID: 16082680 | PDF

Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter.
Misgeld T, Kummer TT, Lichtman JW, Sanes JR.
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11088-93.
PMID: 16043708 | PDF

Peptide tags for labeling membrane proteins in live cells with multiple fluorophores.
McCann CM, Bareyre FM, Lichtman JW, Sanes JR.
Biotechniques. 2005 Jun;38(6):945-52.
PMID: 16018556 | PDF

In vivo imaging of axonal degeneration and regeneration in the injured spinal cord.
Kerschensteiner M, Schwab ME, Lichtman JW, Misgeld T.
Nat Med. 2005 May;11(5):572-7.
PMID: 15821747 | PDF

2004
 
Axon branch removal at developing synapses by axosome shedding.
Bishop DL, Misgeld T, Walsh MK, Gan WB, Lichtman JW.
Neuron. 2004 Nov 18;44(4):651-61.
PMID: 15541313 | PDF

Age-associated synapse elimination in mouse parasympathetic ganglia.
Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW.
J Neurobiol. 2004 Aug;60(2):214-26.
PMID: 15266652 | PDF

Comment on “Reelin promotes peripheral synapse elimination and maturation”.
Bidoia C, Misgeld T, Weinzierl E, Buffelli M, Feng G, Cangiano A, Lichtman JW, Sanes JR.
Science. 2004 Mar 26;303(5666):1977; author reply 1977.
PMID: 15044788 | PDF

Nerve-independent formation of a topologically complex postsynaptic apparatus.
Kummer TT, Misgeld T, Lichtman JW, Sanes JR.
J Cell Biol. 2004 Mar 29;164(7):1077-87.
PMID: 15037598 | PDF

Structural dynamics of synapses in living animals.
Kasthuri N, Lichtman JW.
Curr Opin Neurobiol. 2004 Feb;14(1):105-11. Erratum in: Curr Opin Neurobiol. 2004 Apr;14(2):265-6.
PMID: 15018945 | PDF

2003
 
Watching the neuromuscular junction.
Lichtman JW, Sanes JR.
J Neurocytol. 2003 Jun-Sep;32(5-8):767-75.
PMID: 15034266 | PDF

Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo.
Pan YA, Misgeld T, Lichtman JW, Sanes JR.
J Neurosci. 2003 Dec 10;23(36):11479-88.
PMID: 14673013 | PDF

LTP: perils and progress.
Lisman J, Lichtman JW, Sanes JR.
Nat Rev Neurosci. 2003 Nov;4(11):926-9.
PMID: 14595404 | PDF

Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion.
Gan WB, Kwon E, Feng G, Sanes JR, Lichtman JW.
Nat Neurosci. 2003 Sep;6(9):956-60.
PMID: 12925856 | PDF

Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition.
Buffelli M, Burgess RW, Feng G, Lobe CG, Lichtman JW, Sanes JR.
Nature. 2003 Jul 24;424(6947):430-4.
PMID: 12879071 | PDF

The role of neuronal identity in synaptic competition.
Kasthuri N, Lichtman JW.
Nature. 2003 Jul 24;424(6947):426-30.
PMID: 12879070 | PDF

Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions.
Grady RM, Akaaboune M, Cohen AL, Maimone MM, Lichtman JW, Sanes JR.
J Cell Biol. 2003 Mar 3;160(5):741-52.
PMID: 12604589 | PDF

In vivo time-lapse imaging of synaptic takeover associated with naturally occurring synapse elimination.
Walsh MK, Lichtman JW.
Neuron. 2003 Jan 9;37(1):67-73.
PMID: 12526773 | PDF

2002
 
Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase.
Misgeld T, Burgess RW, Lewis RM, Cunningham JM, Lichtman JW, Sanes JR.
Neuron. 2002 Nov 14;36(4):635-48.
PMID: 12441053 | PDF

Pre-existing pathways promote precise projection patterns.
Nguyen QT, Sanes JR, Lichtman JW.
Nat Neurosci. 2002 Sep;5(9):861-7.
PMID: 12172551 | PDF

Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands.
Akaaboune M, Grady RM, Turney S, Sanes JR, Lichtman JW.
Neuron. 2002 Jun 13;34(6):865-76.
PMID: 12086635 | PDF

2001
 
Induction, assembly, maturation and maintenance of a postsynaptic apparatus.
Sanes JR, Lichtman JW.
Nat Rev Neurosci. 2001 Nov;2(11):791-805.
PMID: 11715056 | PDF

The neuronal naturalist: watching neurons in their native habitat.
Lichtman JW, Fraser SE.
Nat Neurosci. 2001 Nov;4 Suppl:1215-20.
PMID: 11687832 | PDF

Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice.
Keller-Peck CR, Walsh MK, Gan WB, Feng G, Sanes JR, Lichtman JW.
Neuron. 2001 Aug 16;31(3):381-94.
PMID: 11516396 | PDF

Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction.
Keller-Peck CR, Feng G, Sanes JR, Yan Q, Lichtman JW, Snider WD.
J Neurosci. 2001 Aug 15;21(16):6136-46.
PMID: 11487637 | PDF

Getting a bead on receptor movements.
Craig AM, Lichtman JW.
Nat Neurosci. 2001 Mar;4(3):219-20.
PMID: 11224530 | PDF

2000
 
Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.
Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR.
Neuron. 2000 Oct;28(1):41-51.
PMID: 11086982 | PDF

Multicolor “DiOlistic” labeling of the nervous system using lipophilic dye combinations.
Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW.
Neuron. 2000 Aug;27(2):219-25.
PMID: 10985343 | PDF

Nerve terminals form but fail to mature when postsynaptic differentiation is blocked: in vivo analysis using mammalian nerve-muscle chimeras.
Nguyen QT, Son YJ, Sanes JR, Lichtman JW.
J Neurosci. 2000 Aug 15;20(16):6077-86.
PMID: 10934257 | PDF

From plaque to pretzel: fold formation and acetylcholine receptor loss at the developing neuromuscular junction.
Marques MJ, Conchello JA, Lichtman JW.
J Neurosci. 2000 May 15;20(10):3663-75.
PMID: 10804208 | PDF

Synapse elimination and indelible memory.
Lichtman JW, Colman H.
Neuron. 2000 Feb;25(2):269-78..
PMID: 10719884 | PDF

1990-1999
 
Vital imaging and ultrastructural analysis of individual axon terminals labeled by iontophoretic application of lipophilic dye.
Gan WB, Bishop DL, Turney SG, Lichtman JW.
J Neurosci Methods. 1999 Oct 30;93(1):13-20.
PMID: 10598860 | PDF

Activity-driven synapse elimination leads paradoxically to domination by inactive neurons.
Barber MJ, Lichtman JW.
J Neurosci. 1999 Nov 15;19(22):9975-85.
PMID: 10559405 | PDF

Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo.
Akaaboune M, Culican SM, Turney SG, Lichtman JW.
Science. 1999 Oct 15;286(5439):503-7.
PMID: 10521340 | PDF

Can molecules explain long-term potentiation?
Sanes JR, Lichtman JW.
Nat Neurosci. 1999 Jul;2(7):597-604.
PMID: 10404178 | PDF

Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.
Burgess RW, Nguyen QT, Son YJ, Lichtman JW, Sanes JR.
Neuron. 1999 May;23(1):33-44.
PMID: 10402191 | PDF

Axonal atrophy: the retraction reaction.
Bernstein M, Lichtman JW.
Curr Opin Neurobiol. 1999 Jun;9(3):364-70. Review.
PMID: 10395581 | PDF

Development of the vertebrate neuromuscular junction.
Sanes JR, Lichtman JW.
Annu Rev Neurosci. 1999;22:389-442.
PMID: 10202544 | PDF

Synaptic segregation at the developing neuromuscular junction.
Gan WB, Lichtman JW.
Science. 1998 Nov 20;282(5393):1508-11.

PMID: 9822385 | PDF
Development of the neuromuscular junction: genetic analysis in mice.
Sanes JR, Apel ED, Burgess RW, Emerson RB, Feng G, Gautam M, Glass D, Grady RM, Krejci E, Lichtman JW, Lu JT, Massoulié J, Miner JH, Moscoso LM, Nguyen Q, Nichol M, Noakes PG, Patton BL, Son YJ, Yancopoulos GD, Zhou H.
J Physiol Paris. 1998 Jun-Aug;92(3-4):167-72.
PMID: 9789802 | PDF

Synaptic competition during the reformation of a neuromuscular map.
Laskowski MB, Colman H, Nelson C, Lichtman JW.
J Neurosci. 1998 Sep 15;18(18):7328-35.
PMID: 9736653 | PDF

Axon withdrawal during synapse elimination at the neuromuscular junction is accompanied by disassembly of the postsynaptic specialization and withdrawal of Schwann cell processes.
Culican SM, Nelson CC, Lichtman JW.
J Neurosci. 1998 Jul 1;18(13):4953-65.
PMID: 9634561 | PDF

Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle.
Nguyen QT, Parsadanian AS, Snider WD, Lichtman JW.
Science. 1998 Mar 13;279(5357):1725-9.
PMID: 9497292 | PDF

Alterations in synaptic strength preceding axon withdrawal.
Colman H, Nabekura J, Lichtman JW.
Science. 1997 Jan 17;275(5298):356-61.
PMID: 8994026 | PDF

Are neurotrophins synaptotrophins?
Snider WD, Lichtman JW.
Mol Cell Neurosci. 1996 Jun;7(6):433-42.
PMID: 8875427 | PDF

Mechanism of synapse disassembly at the developing neuromuscular junction.
Nguyen QT, Lichtman JW.
Curr Opin Neurobiol. 1996 Feb;6(1):104-12.
PMID: 8794054 | PDF

A quantitative fluorescence-imaging technique for studying acetylcholine receptor turnover at neuromuscular junctions in living animals.
Turney SG, Culican SM, Lichtman JW.
J Neurosci Methods. 1996 Feb;64(2):199-208.
PMID: 8699881 | PDF

Brief communication: some observations on enamel thickness and enamel prism packing in the Miocene hominoid Otavipithecus namibiensis.
Conroy GC, Lichtman JW, Martin LB.
Am J Phys Anthropol. 1995 Dec;98(4):595-600.
PMID: 8599388 | PDF

Long-term synapse loss induced by focal blockade of postsynaptic receptors.
Balice-Gordon RJ, Lichtman JW.
Nature. 1994 Dec 8;372(6506):519-24.
PMID: 7990923 | PDF

In vivo imaging shows loss of synaptic sites from neuromuscular junctions in a model of myasthenia gravis.
Rich MM, Colman H, Lichtman JW.
Neurology. 1994 Nov;44(11):2138-45.
PMID: 7969973 | PDF

Regenerating muscle fibers induce directional sprouting from nearby nerve terminals: studies in living mice.
van Mier P, Lichtman JW.
J Neurosci. 1994 Sep;14(9):5672-86.
PMID: 8083762 | PDF

Theoretical analysis of a rotating-disk partially confocal scanning microscope.
Conchello JA, Lichtman JW.
Appl Opt. 1994 Feb 1;33(4):585-96.
PMID: 20862053 | PDF

Gradual loss of synaptic cartels precedes axon withdrawal at developing neuromuscular junctions.
Balice-Gordon RJ, Chua CK, Nelson CC, Lichtman JW.
Neuron. 1993 Nov;11(5):801-15.
PMID: 8240805 | PDF

Interactions between nerve and muscle: synapse elimination at the developing neuromuscular junction.
Colman H, Lichtman JW.
Dev Biol. 1993 Mar;156(1):1-10.
PMID: 8449362 | PDF

In vivo observations of pre- and postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions.
Balice-Gordon RJ, Lichtman JW.
J Neurosci. 1993 Feb;13(2):834-55.
PMID: 8426240 | PDF

‘Cartellian’ competition at the neuromuscular junction.
Colman H, Lichtman JW.
Trends Neurosci. 1992 Jun;15(6):197-9.
PMID: 1378660 | PDF

Neurobiology. From cell line to brain.
Sanes JR, Lichtman JW.
Nature. 1992 Apr 16;356(6370):562-3.
PMID: 1560839 | PDF

Neuromuscular junctions shrink and expand as muscle fiber size is manipulated: in vivo observations in the androgen-sensitive bulbocavernosus muscle of mice.
Balice-Gordon RJ, Breedlove SM, Bernstein S, Lichtman JW.
J Neurosci. 1990 Aug;10(8):2660-71.
PMID: 2388082 | PDF

In vivo visualization of the growth of pre- and postsynaptic elements of neuromuscular junctions in the mouse.
Balice-Gordon RJ, Lichtman JW.
J Neurosci. 1990 Mar;10(3):894-908.
PMID: 2156964 | PDF

Understanding synaptic competition in theory and in practice.
Lichtman JW, Balice-Gordon RJ.
J Neurobiol. 1990 Jan;21(1):99-106.
PMID: 2181069 | PDF

1989 and before

Motor nerve terminal loss from degenerating muscle fibers.
Rich M, Lichtman JW.
Neuron. 1989 Dec;3(6):677-88.
PMID: 2642014 | PDF

High-resolution imaging of synaptic structure with a simple confocal microscope.
Lichtman JW, Sunderland WJ, Wilkinson RS.
New Biol. 1989 Oct;1(1):75-82.
PMID: 2488274 | PDF

In vivo visualization of pre- and postsynaptic changes during synapse elimination in reinnervated mouse muscle.
Rich MM, Lichtman JW.
J Neurosci. 1989 May;9(5):1781-805.
PMID: 2542480 | PDF

Properties of motor units in the transversus abdominis muscle of the garter snake.
Lichtman JW, Wilkinson RS.
J Physiol. 1987 Dec;393:355-74.
PMID: 3446800 | PDF

Synaptic sites on reinnervated nerve cells visualized at two different times in living mice.
Purves D, Lichtman JW.
J Neurosci. 1987 May;7(5):1492-7.
PMID: 3572488 | PDF

Visualization of neuromuscular junctions over periods of several months in living mice.
Lichtman JW, Magrassi L, Purves D.
J Neurosci. 1987 Apr;7(4):1215-22.
PMID: 3572477 | PDF

Fluorescent probes that stain living nerve terminals.
Magrassi L, Purves D, Lichtman JW.
J Neurosci. 1987 Apr;7(4):1207-14.
PMID: 3572476 | PDF

Developmental neurobiology. Trophic factor theory matures.
Lichtman JW, Taghert PH.
Nature. 1987 Mar 26-Apr 1;326(6111):336..
PMID: 3031503 | PDF

Rearrangement of synapses during development.
Lichtman JW.
NIDA Res Monogr. 1987;78:15-29.
PMID: 3123986 | PDF

Developmental neurobiology. Axon outgrowth in vertebrates.
Taghert PH, Lichtman JW.
Nature. 1986 Mar 20-26;320(6059):210-11.
PMID: 3960104 | PDF

Regular alternation of fiber types in the transversus abdominis muscle of the garter snake.
Wilkinson RS, Lichtman JW.
J Neurosci. 1985 Nov;5(11):2979-88.
PMID: 2414418 | PDF

Geometrical differences among homologous neurons in mammals.
Purves D, Lichtman JW.
Science. 1985 Apr 19;228(4697):298-302.
PMID: 3983631 | PDF

Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes.
Lichtman JW, Wilkinson RS, Rich MM.
Nature. 1985 Mar 28-Apr 3;314(6009):357-9.
PMID: 3982503 | PDF

Anatomical basis of specific connections between sensory axons and motor neurons in the brachial spinal cord of the bullfrog.
Lichtman JW, Jhaveri S, Frank E.
J Neurosci. 1984 Jul;4(7):1754-63.
PMID: 6610729 | PDF

Physiological evidence for specificity of synaptic connections between individual sensory and motor neurons in the brachial spinal cord of the bullfrog.
Lichtman JW, Frank E.
J Neurosci. 1984 Jul;4(7):1745-53.
PMID: 6610728 | PDF

Activity-mediated neural change.
Lichtman JW, Purves D.
Nature. 1983 Feb 17-23;301(5901):563.
PMID: 6828137 | PDF

Specific connections between nerve cells.
Purves D, Lichtman JW.
Annu Rev Physiol. 1983;45:553-65.

PMID: 6847165 | PDF
Elimination of synapses in the developing nervous system.

Purves D, Lichtman JW.
Science. 1980 Oct 10;210(4466):153-7.
PMID: 7414326 | PDF

On the predominantly single innervation of submandibular ganglion cells in the rat.
Lichtman JW.
J Physiol. 1980 May;302:121-30.

PMID: 7411451 | PDF
The elimination of redundant preganglionic innervation to hamster sympathetic ganglion cells in early post-natal life.

Lichtman JW, Purves D.
J Physiol. 1980 Apr;301:213-28.
PMID: 7411428 | PDF

Innervation of sympathetic neurones in the guinea-pig thoracic chain.
Lichtman JW, Purves D, Yip JW.
J Physiol. 1980 Jan;298:285-99.
PMID: 7359403 | PDF

On the purpose of selective innervation of guinea-pig superior cervical ganglion cells.
Lichtman JW, Purves D, Yip JW.
J Physiol. 1979 Jul;292:69-84.
PMID: 490406 | PDF

Formation and maintenance of synaptic connections in autonomic ganglia.
Purves D, Lichtman JW.
Physiol Rev. 1978 Oct;58(4):821-62.
PMID: 360252 | PDF

The reorganization of synaptic connexions in the rat submandibular ganglion during post-natal development.
Lichtman JW.
J Physiol. 1977 Dec;273(1):155-77.
PMID: 599418 | PDF

Inhibition of the mitochondrial respiratory chain by alkylhydroxynaphtoquines: reversal on discharge of the energized state.
Howland JL, Lichtman JW, Settlemire CT.
Biochim Biophys Acta. 1973 Aug 31;314(2):154-63.
PMID: 4126990 | PDF