#  Papers 

 



**2025**

[**Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning**](https://www.sciencedirect.com/science/article/pii/S1053811925002150)

Tian, Q., Ngamsombat, C., Lee, H.H., Berger, D.R., Wu, Y., Fan, Q., Bilgic, B., Li, Z., Novikov, D.S., Fieremans, E. and Rosen, B.R., 2025. Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning. *NeuroImage*, *313*, p.121212.

[**SmartEM: machine learning-guided electron microscopy**](https://www.nature.com/articles/s41592-025-02929-3)

Meirovitch, Y., Chandok, I.S., Park, C.F., Potocek, P., Mi, L., Sawmya, S., Li, Y., Athey, T.L., Susoy, V., Karlupia, N. and Wu, Y., 2025. SmartEM: machine learning-guided electron microscopy. *Nature Methods*, pp.1-12.

**2024**

[**A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution**](https://www.science.org/doi/abs/10.1126/science.adk4858)

Shapson-Coe, A., Januszewski, M., Berger, D.R., Pope, A., Wu, Y., Blakely, T., Schalek, R.L., Li, P.H., Wang, S., Maitin-Shepard, J. and Karlupia, N., 2024. A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution. *Science*, *384*(6696), p.eadk4858.

[**A neural algorithm for computing bipartite matchings**](https://www.pnas.org/doi/10.1073/pnas.2321032121)

Dasgupta, S., Meirovitch, Y., Zheng, X., Bush, I., Lichtman, J.W. and Navlakha, S., 2024. A neural algorithm for computing bipartite matchings. *Proceedings of the National Academy of Sciences*, *121*(37), p.e2321032121.

[**Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex**](https://www.nature.com/articles/s41467-024-50411-z)

Han, X., Lu, X., Li, P.H., Wang, S., Schalek, R., Meirovitch, Y., Lin, Z., Adhinarta, J., Murray, K.D., MacNiven, L.M. and Berger, D.R., 2024. Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. *Nature communications*, *15*(1), p.6648.

[**Two-stage error detection to improve electron microscopy image mosaicking**](https://www.sciencedirect.com/science/article/abs/pii/S0010482524005407)

Shi, J., Ge, H., Wang, S., Wei, D., Yang, J., Cheng, A., Schalek, R., Guo, J., Lichtman, J., Wang, L. and Zhang, R., 2024. Two-stage error detection to improve electron microscopy image mosaicking. *Computers in Biology and Medicine*, *178*, p.108456.

[**High-throughput ultrastructural analysis of macular telangiectasia type 2**](https://www.frontiersin.org/journals/ophthalmology/articles/10.3389/fopht.2024.1428777/full)

Zucker, C.L., Bernstein, P.S., Schalek, R.L., Lichtman, J.W. and Dowling, J.E., 2024. High-throughput ultrastructural analysis of macular telangiectasia type 2. *Frontiers in Ophthalmology*, *4*, p.1428777.

[**Extensive soma-soma plate-like contact sites (ephapses) connect suprachiasmatic nucleus neurons**](https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.25624)

Czeisler, M.É., Shan, Y., Schalek, R., Berger, D.R., Suissa‐Peleg, A., Takahashi, J.S. and Lichtman, J.W., 2024. Extensive soma‐soma plate‐like contact sites (ephapses) connect suprachiasmatic nucleus neurons. *Journal of Comparative Neurology*, *532*(6), p.e25624.

[**Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex**](https://www.cell.com/neuron/fulltext/S0896-6273(23)00719-5)

Wu, J.Y., Cho, S.J., Descant, K., Li, P.H., Shapson-Coe, A., Januszewski, M., Berger, D.R., Meyer, C., Casingal, C., Huda, A. and Liu, J., 2024. Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex. *Neuron*, *112*(1), pp.41-55.

**2023**

[**Multi-layered maps of neuropil with segmentation-guided contrastive learning**](https://www.nature.com/articles/s41592-023-02059-8)

Dorkenwald, S., Li, P.H., Januszewski, M., Berger, D.R., Maitin-Shepard, J., Bodor, A.L., Collman, F., Schneider-Mizell, C.M., da Costa, N.M., Lichtman, J.W. and Jain, V., 2023. Multi-layered maps of neuropil with segmentation-guided contrastive learning. *Nature Methods*, *20*(12), pp.2011-2020.

[**Immersion Fixation and Staining of Multicubic Millimeter Volumes for Electron Microscopy–Based Connectomics of Human Brain Biopsies**](https://www.sciencedirect.com/science/article/abs/pii/S0006322323000537)

Karlupia, N., Schalek, R.L., Wu, Y., Meirovitch, Y., Wei, D., Charney, A.W., Kopell, B.H. and Lichtman, J.W., 2023. Immersion fixation and staining of multicubic millimeter volumes for electron microscopy–based connectomics of human brain biopsies. *Biological Psychiatry*, *94*(4), pp.352-360.

[**Preserving extracellular space for high-quality optical and ultrastructural studies of whole mammalian brain**](https://lichtman.backup.projects.iq.harvard.edu/www.cell.com/cell-reports-methods/fulltext/S2667-2375(23)00149-2?dgcid=raven_jbs_etoc_email)

Lu, X., Han, X., Meirovitch, Y., Sjöstedt, E., Schalek, R.L. and Lichtman, J.W., 2023. Preserving extracellular space for high-quality optical and ultrastructural studies of whole mammalian brains. *Cell reports methods*, *3*(7).

[**Connectomics of the Octopus vulgaris vertical lobe provides insight into conserved and novel principles of a memory acquisition network**](https://elifesciences.org/articles/84257)

Bidel, F., Meirovitch, Y., Schalek, R.L., Lu, X., Pavarino, E.C., Yang, F., Peleg, A., Wu, Y., Shomrat, T., Berger, D.R. and Shaked, A., 2023. Connectomics of the Octopus vulgaris vertical lobe provides insight into conserved and novel principles of a memory acquisition network. *Elife*, *12*, p.e84257.

[**mEMbrain: an interactive deep learning MATLAB tool for connectomic segmentation on commodity desktops**](https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2023.952921/full)

Pavarino, E.C., Yang, E., Dhanyasi, N., Wang, M.D., Bidel, F., Lu, X., Yang, F., Francisco Park, C., Bangalore Renuka, M., Drescher, B. and Samuel, A.D., 2023. mEMbrain: an interactive deep learning MATLAB tool for connectomic segmentation on commodity desktops. *Frontiers in Neural Circuits*, *17*, p.952921.

[**3D reconstruction of the cerebellar germinal layer reveals tunneling connections between developing granule cells**](https://www.science.org/doi/full/10.1126/sciadv.adf3471)

Cordero Cervantes, D., Khare, H., Wilson, A. M., Mendoza, N. D., Coulon-Mahdi, O., Lichtman, J. W., & Zurzolo, C. (2023). 3D reconstruction of the cerebellar germinal layer reveals tunneling connections between developing granule cells. *Science Advances*, *9*(14), eadf3471.

**2022**

[**Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish**](https://www.cell.com/current-biology/fulltext/S0960-9822(21)01530-X)

Odstrcil, I., Petkova, M.D., Haesemeyer, M., Boulanger-Weill, J., Nikitchenko, M., Gagnon, J.A., Oteiza, P., Schalek, R., Peleg, A., Portugues, R. and Lichtman, J.W., 2022. Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish. *Current Biology*, *32*(1), pp.176-189.

[**Axonal Regeneration Through Autologous Grafts: Does the Axonal Load Influence Regeneration?**](https://www.sciencedirect.com/science/article/abs/pii/S0022480422004929)

Leckenby, J.I., Chacon, M.A., Milek, D., Lichtman, J.W. and Grobbelaar, A.O., 2022. Axonal Regeneration Through Autologous Grafts: Does the Axonal Load Influence Regeneration?. *Journal of Surgical Research*, *280*, pp.379-388.

[**Post-embryonic remodeling of the C. elegans motor circuit**](https://www.cell.com/current-biology/fulltext/S0960-9822(22)01610-4)

Mulcahy, B., Witvliet, D.K., Mitchell, J., Schalek, R., Berger, D.R., Wu, Y., Holmyard, D., Lu, Y., Ahamed, T., Samuel, A.D. and Chisholm, A.D., 2022. Post-embryonic remodeling of the C. elegans motor circuit. *Current Biology*, *32*(21), pp.4645-4659.

[**Connectomics Annotation Metadata Standardization for Increased Accessibility and Queryability**](https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2022.828458/full)

Sanchez, M., Moore, D., Johnson, E.C., Wester, B., Lichtman, J.W. and Gray-Roncal, W., 2022. Connectomics Annotation Metadata Standardization for Increased Accessibility and Queryability. *Frontiers in Neuroinformatics*, *16*, p.828458.

**2021**

[**Tissue clearing**](https://www.nature.com/articles/s43586-021-00080-9)

Richardson, D.S., Guan, W., Matsumoto, K., Pan, C., Chung, K., Ertürk, A., Ueda, H.R. and Lichtman, J.W., 2021. Tissue clearing. *Nature Reviews Methods Primers*, *1*(1), p.84.

[**Connectomes across development reveal principles of brain maturation**](https://www.nature.com/articles/s41586-021-03778-8)

Witvliet, D., Mulcahy, B., Mitchell, J.K., Meirovitch, Y., Berger, D.R., Wu, Y., Liu, Y., Koh, W.X., Parvathala, R., Holmyard, D. and Schalek, R.L., 2021. Connectomes across development reveal principles of brain maturation. *Nature*, *596*(7871), pp.257-261.

[**Optical Multilayer Interference Tomography Compatible with Tape-Based Serial SEM for Mesoscale Neuroanatomy**](https://pubs.acs.org/doi/full/10.1021/acsphotonics.1c00892)

Fan, H., Luo, D., Zhu, J., Schalek, R.L., Chen, Z., Zhao, L., Zhou, R., Sun, M., Shi, G., Xie, Y. and Lichtman, J.W., 2021. Optical multilayer interference tomography compatible with tape-based serial SEM for mesoscale neuroanatomy. *ACS Photonics*, *9*(1), pp.25-33.

[**Connectome 2.0: Developing the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso- and macro-connectome**](https://www.sciencedirect.com/science/article/pii/S105381192100803X)

Huang, S.Y., Witzel, T., Keil, B., Scholz, A., Davids, M., Dietz, P., Rummert, E., Ramb, R., Kirsch, J.E., Yendiki, A. and Fan, Q., 2021. Connectome 2.0: Developing the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso-and macro-connectome. *NeuroImage*, *243*, p.118530.

[**Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies**](https://onlinelibrary.wiley.com/doi/abs/10.1002/dneu.22829)

Ofer, N., Berger, D.R., Kasthuri, N., Lichtman, J.W. and Yuste, R., 2021. Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies. *Developmental neurobiology*, *81*(5), pp.746-757.

**2020**  
  
[**An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus**](https://www.sciencedirect.com/science/article/pii/S0896627320301008#cebib0010)

Morgan, J. L., & Lichtman, J. W. (2020). An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus. *Neuron*, *106*(3). doi: 10.1016/j.neuron.2020.02.001

**2019**

[**Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex**](https://www.sciencedirect.com/science/article/pii/S2211124719306291?via=ihub)

Zonouzi M, Berger D, Jokhi V, Kedaigle A, Lichtman J, Arlotta P. Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex. Cell Rep. 2019 Jun 4;27(10):2799-2808.e3. doi: 10.1016/j.celrep.2019.05.018. PubMed PMID: 31167127.

[**Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM)**](https://www.sciencedirect.com/science/article/pii/S0091679X1930055X?via=ihub)

Baena V, Schalek RL, Lichtman JW, Terasaki M. Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM). Methods Cell Biol.2019;152:41-67. doi: 10.1016/bs.mcb.2019.04.004. Epub 2019 Jun 8. PubMed PMID: 31326026.

[**Imaging Peripheral Nerve Regeneration: A New Technique for 3D Visualization of Axonal Behavior**](https://www.sciencedirect.com/science/article/pii/S002248041930232X?via=ihub)

Leckenby JI, Chacon MA, Grobbelaar AO, Lichtman JW. Imaging Peripheral Nerve Regeneration: A New Technique for 3D Visualization of Axonal Behavior. J Surg Res.2019 Oct;242:207-213. doi: 10.1016/j.jss.2019.04.046. Epub 2019 May 11. PubMed PMID: 31085369.

[**Development of the interscutularis model as an outcome measure for facial nerve surgery**](https://www.sciencedirect.com/science/article/pii/S0940960219300305?via=ihub)

Leckenby JI, Chacon MA, Rolfe K, Lichtman JW, Grobbelaar AO. Development of the interscutularis model as an outcome measure for facial nerve surgery. Ann Anat. 2019 May;223:127-135. doi: 10.1016/j.aanat.2019.03.001. Epub 2019 Mar 22. PubMed PMID: 30910682.

[**2018**](/2017-1)

[**Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405223/)

Fang T, Lu X, Berger D, Gmeiner C, Cho J, Schalek R, Ploegh H, Lichtman J. Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure. Nat Methods. 2018 Dec;15(12):1029-1032. doi: 10.1038/s41592-018-0177-x. Epub 2018 Nov 5. PubMed PMID: 30397326; PubMed Central PMCID: PMC6405223.

[**VAST (Volume Annotation and Segmentation Tool): Efficient Manual and Semi-Automatic Labeling of Large 3D Image Stacks**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198149/)

Berger DR, Seung HS, Lichtman JW. VAST (Volume Annotation and Segmentation Tool): Efficient Manual and Semi-Automatic Labeling of Large 3D Image Stacks. *Front Neural Circuits*. 2018;12:88. Published 2018 Oct 16. doi:10.3389/fncir.2018.00088

[**Inhibitory circuit gating of auditory critical period plasticity**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978727/)

Takesian AE, Bogart LJ, Lichtman JW, Hensch TK. Inhibitory circuit gating of auditory critical-period plasticity. *Nat Neurosci*. 2018;21(2):218-227.

**2017**

[**Efficiency of Cathodoluminescence Emmision by Nitrogen-Vacancy Color Centers in Nanodiamond**](https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201700543)

Zhang H, Glenn DR, Schalek R, Lichtman JK, Walsworth RL. 2016. Efficiency of Cathodoluminescence Emmision by Nitrogen-Vacancy Color Centers in Nanodiamond. arXiv:1602.00410.

[**Digital tissue and what it may reveal about the brain**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663051/)

Morgan, J. L., & Lichtman, J. W. (2017). Digital tissue and what it may reveal about the brain. *BMC Biology* (in press)

[**Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315461/)

Sheu SH, Tapia JC, Tsuriel S, Lichtman JW. Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice. *Elife*. 2017;6:e23193. Published 2017 Feb 3. doi:10.7554/eLife.23193

[**Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator.**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569574/)

Vishwanathan A, Daie K, Ramirez AD, Lichtman JW, Aksay ERF, Seung HS. Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator. *Curr Biol*. 2017;27(14):2137-2147.e3.

**2016**

[**The fuzzy logic of network connectivity in mouse visual thalamus**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808248/)

Morgan JL, Berger DR, Wetzel AW, Lichtman JW. The fuzzy logic of network connectivity in mouse visual thalamus. *Cell*. 2016;165(1):192-206. doi:10.1016/j.cell.2016.02.033.

PMCID: PMC4808248

[**From**](https://www.annualreviews.org/doi/full/10.1146/annurev-neuro-071714-033954?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed&) [**Cajal to Connectome and Beyond**](https://www.annualreviews.org/doi/full/10.1146/annurev-neuro-071714-033954?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed&)

Swanson LW and Lichtman JW. 2016. From Cajal to Connectome and Beyoond. Annu. Rev. Neurosci., 2016. 39:197-216, doi: 10.1146/annurev-neuro-0717140033954. PMID: 27442070

[**Icon: An interactive approach to train deep neural networks for segmentation of neuronal structures**](https://arxiv.org/pdf/1610.09032.pdf)

Gonda F, Kaynig V, Thouis R, Haehn D, Lichtman JW, Parag T, Pfister H. (2016). ICON: An interactive approach to train deep neural networks for segmentation of neuronal structures. Submitted Oct. 27, 2016

**2015**

[**Saturated Reconstruction of a Volume of Neocortex.**](https://www.sciencedirect.com/science/article/pii/S0092867415008247?via=ihub)

Kasthuri N, Hayworth KJ, Berger DR, Schalek RL, Conchello JA, Knowles-Barley S, Lee D, Vázquez-Reina A, Kaynig V, Jones TR, Roberts M, Morgan JL, Tapia JC, Seung HS, Roncal WG, Vogelstein JT, Burns R, Sussman DL, Priebe CE, Pfister H, Lichtman JW. *Cell*. 2015 Jul 30;162(3):648-61. doi: 10.1016/j.cell.2015.06.054. PMID: 26232230

[**Clarifying tissue Clearing**](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537058/)

Richardson DS, Lichtman JW.*Cell*. 2015 Jul 16;162(2):246-57. doi: 10.1016/j.cell.2015.06.067. Review. PMID: 26186186  
  
[**Multispectral labeling technique to map many neighboring axonal projections in the same tissue.**](http://www.ncbi.nlm.nih.gov/pubmed/25915122)  
Tsuriel S, Gudes S, Draft RW, Binshtok AM, Lichtman JW.  
*Nat Methods*. 2015 Apr 27. doi: 10.1038/nmeth.3367. \[Epub ahead of print\] PMID: 25915122

[**Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics.**](http://www.ncbi.nlm.nih.gov/pubmed/25686390)

Hayworth KJ, Xu CS, Lu Z, Knott GW, Fetter RD, Tapia JC, Lichtman JW, Hess HF.

*Nat Methods*. 2015 Apr;12(4):319-22. doi: 10.1038/nmeth.3292. Epub 2015 Feb 16. PMID: 25686390

[**High-resolution, high-throughput imaging with a multibeam scanning electron microscope.**](http://www.ncbi.nlm.nih.gov/pubmed/25627873)

Eberle AL, Mikula S, Schalek R, Lichtman JW, Tate ML, Zeidler D.

*J Microsc*. 2015 Jan 27. doi: 10.1111/jmi.12224. \[Epub ahead of print\] PMID: 25627873

**2014**

**The big data challenges of connectomics.**

Lichtman JW, Pfister H, Shavit N. *Neurosci*. 2014 Nov;17(11):1448-54. doi: 10.1038/nn.3837. Epub 2014 Oct 28. Review. PMID: 25349911

**Imaging ATUM ultrathin section libraries with WaferMapper: a multi-scale approach to EM reconstruction of neural circuits.**  
Hayworth KJ, Morgan JL, Schalek R, Berger DR, Hildebrand DG, Lichtman JW. *Front Neural Circuits.* 2014 Jun 27;8:68. doi: 10.3389/fncir.2014.00068. eCollection 2014.  
PMID: 2501870

  
**Exploring the connectome: petascale volume visualization of microscopy data streams.**  
Beyer J, Hadwiger M, Al-Awami A, Jeong WK, Kasthuri N, Lichtman JW, Pfister H. *IEEE Comput Graph Appl.* 2013 Jul-Aug;33(4):50-61. doi: 10.1109/MCG.2013.55.  
PMID: 24808059

**Terminal Schwann cells participate in neuromuscular synapse remodeling during reinnervation following nerve injury.**  
Kang H, Tian L, Mikesh M, Lichtman JW, Thompson WJ. *J Neurosci.* 2014 Apr 30;34(18):6323-33. doi: 10.1523/JNEUROSCI.4673-13.2014. PMID: 24790203

**Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling.**  
Shvartsman D, Storrie-White H, Lee K, Kearney C, Brudno Y, Ho N, Cezar C, McCann C, Anderson E, Koullias J, Tapia JC, Vandenburgh H, Lichtman JW, Mooney DJ.  
*Mol Ther.* 2014 Jul;22(7):1243-53. doi: 10.1038/mt.2014.76. Epub 2014 Apr 28.  
PMID: 24769910

**Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex.**  
Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. *Science.* 2014 Apr 18;344(6181):319-24. doi: 10.1126/science.1249766. PMID: 24744380

**Silicon-vacancy color centers in nanodiamonds: cathodoluminescence imaging markers in the near infrared.**  
Zhang H, Aharonovich I, Glenn DR, Schalek R, Magyar AP, Lichtman JW, Hu EL, Walsworth RL. *Small.* 2014 May 28;10(10):1908-13. doi: 10.1002/smll.201303582. Epub 2014 Mar 4. No abstract available. PMID: 24596272

**2013**

**Motor axon regeneration and muscle reinnervation in young adult and aged animals.**  
Kang H, Lichtman JW. *J Neurosci.* 2013 Dec 11;33(50):19480-91. doi: 10.1523/JNEUROSCI.4067-13.2013. PMID: 24336714

**ConnectomeExplorer: query-guided visual analysis of large volumetric neuroscience data.**  
Beyer J, Al-Awami A, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. *IEEE Trans Vis Comput Graph.* 2013 Dec;19(12):2868-77. doi: 10.1109/TVCG.2013.142. PMID: 24051854

**Developmental bias in cleavage-stage mouse blastomeres.**  
Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K. *Curr Biol.* 2013 Jan 7;23(1):21-31.  
[PMID: 23177476 ](http://www.ncbi.nlm.nih.gov/pubmed/23177476)| PDF

**Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs.**  
Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM.  
*Cell*. 2013 Jul 18;154(2):285-96.  
[PMID: 23870120](http://www.ncbi.nlm.nih.gov/pubmed/23870120) | PDF

**Improved tools for the Brainbow toolbox.**  
Cai D, Cohen KB, Luo T, Lichtman JW, Sanes JR.  
*Nat Methods*. 2013 Jun;10(6):540-7.  
[PMID: 23866336 ](http://www.ncbi.nlm.nih.gov/pubmed/23866336)| PDF

**Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish.**  
Pan YA, Freundlich T, Weissman TA, Schoppik D, Wang XC, Zimmerman S, Ciruna B, Sanes JR, Lichtman JW, Schier AF.  
*Development.* 2013 Jul;140(13):2835-46.  
[PMID: 23757414](http://www.ncbi.nlm.nih.gov/pubmed/23757414) | PDF

**Why not connectomics?**  
Morgan JL, Lichtman JW.  
*Nat Methods.* 2013 Jun;10(6):494-500.  
[PMID: 23722208](http://www.ncbi.nlm.nih.gov/pubmed/23722208) | PDF

**2012**

**Correlative light and electron microscopy using cathodoluminescence from nanoparticles with distinguishable colours.**  
Glenn DR, Zhang H, Kasthuri N, Schalek R, Lo PK, Trifonov AS, Park H, Lichtman JW, Walsworth RL.  
*Sci Rep.* 2012;2:865.  
[PMID: 23155483](http://www.ncbi.nlm.nih.gov/pubmed/23155483) | [PDF](/file_url/115)

**In vivo imaging of the developing neuromuscular junction in neonatal mice.**  
Turney SG, Walsh MK, Lichtman JW.  
*Cold Spring Harb Protoc.* 2012 Nov 1;2012(11):1166-76.  
[PMID: 23118362](http://www.ncbi.nlm.nih.gov/pubmed/23118362) | PDF

**Agrin and synaptic laminin are required to maintain adult neuromuscular junctions.**  
Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR.  
*PLoS One.* 2012;7(10):e46663.  
[PMID: 23056392 ](http://www.ncbi.nlm.nih.gov/pubmed/23056392)| [PDF](/file_url/114)

**Reversing the outcome of synapse elimination at developing neuromuscular junctions in vivo: evidence for synaptic competition and its mechanism.**  
Turney SG, Lichtman JW.  
*PLoS Biol.* 2012;10(6):e1001352.  
[PMID: 22745601](http://www.ncbi.nlm.nih.gov/pubmed/22745601) | [PDF](/file_url/116)

**Pervasive synaptic branch removal in the mammalian neuromuscular system at birth.**  
Tapia JC, Wylie JD, Kasthuri N, Hayworth KJ, Schalek R, Berger DR, Guatimosim C, Seung HS, Lichtman JW.  
*Neuron.* 2012 Jun 7;74(5):816-29. doi: 10.1016/j.neuron.2012.04.017.  
[PMID: 22681687](http://www.ncbi.nlm.nih.gov/pubmed/22681687) | PDF

**Shared resistance to aging and ALS in neuromuscular junctions of specific muscles.**  
Valdez G, Tapia JC, Lichtman JW, Fox MA, Sanes JR.  
*PLoS One.* 2012;7(4):e34640.  
[PMID: 22485182](http://www.ncbi.nlm.nih.gov/pubmed/22485182) | [PDF](/file_url/117)

**High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy.**  
Tapia JC, Kasthuri N, Hayworth KJ, Schalek R, Lichtman JW, Smith SJ, Buchanan J.  
*Nat Protoc*. 2012 Jan 12;7(2):193-206.  
[PMID: 22240582](http://www.ncbi.nlm.nih.gov/pubmed/22240582) |[ PDF](/file_url/118)

**Mouse transgenic lines that selectively label Type I, Type IIA, and** Types IIX+B skeletal muscle fibers. Chakkalakal JV, Kuang S, Buffelli M, Lichtman JW, Sanes JR.  
*Genesis*. 2012 Jan;50(1):50-8.  
[PMID: 21898764](http://www.ncbi.nlm.nih.gov/pubmed/21898764) | PDF

**2011**

**The big and the small: challenges of imaging the brain’s circuits.**  
Lichtman JW, Denk W.  
*Science*. 2011 Nov 4;334(6056):618-23.  
PMID: 22053041 | PDF

**Spatial constraints dictate glial territories at murine neuromuscular junctions.**  
Brill MS, Lichtman JW, Thompson W, Zuo Y, Misgeld T.  
*J Cell Biol*. 2011 Oct 17;195(2):293-305.  
PMID: 22006952 | PDF

**Generating and imaging multicolor Brainbow mice.**  
Weissman TA, Sanes JR, Lichtman JW, Livet J.  
*Cold Spring Harb Protoc*. 2011 Jul 1;2011(7):763-9.  
PMID: 21724826 | PDF

**Generation and imaging of Brainbow mice.**  
Weissman TA, Sanes JR, Lichtman JW, Livet J.  
*Cold Spring Harb Protoc*. 2011 Jul 1;2011(7):851-6.  
PMID: 21724817 | PDF

**Delayed synapse elimination in mouse levator palpebrae superioris muscle.**  
Fox MA, Tapia JC, Kasthuri N, Lichtman JW.  
*J Comp Neurol*. 2011 Oct 15;519(15):2907-21.  
PMID: 21681746 | PDF

**Multicolor Brainbow imaging in zebrafish.**  
Pan YA, Livet J, Sanes JR, Lichtman JW, Schier AF.  
*Cold Spring Harb Protoc*. 2011 Jan 1;2011(1):pdb.prot5546.  
PMID: 21205846 | PDF

**2010**  
**Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise.**  
Valdez G, Tapia JC, Kang H, Clemenson GD Jr, Gage FH, Lichtman JW, Sanes JR.  
*Proc Natl Acad Sci U S A*. 2010 Aug 17;107(33):14863-8.  
PMID: 20679195 | PDF

**Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria. Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D.**  
***J Biol Chem*****. 2010 Aug 27;285(35):27411-7.**  
**PMID: 20551319 | PDF**

**Ballistic delivery of dyes for structural and functional studies of the nervous system.**  
Gan WB, Grutzendler J, Wong RO, Lichtman JW.  
*Cold Spring Harb Protoc*. 2009 Apr;2009(4):pdb.prot5202.  
PMID: 20147144 | PDF

**Neurocartography.**  
Kasthuri N, Lichtman JW.  
*Neuropsychopharmacology*. 2010 Jan;35(1):342-3.  
PMID: 20010709 | PDF

**Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors.**  
Borselli C, Storrie H, Benesch-Lee F, Shvartsman D, Cezar C, Lichtman JW, Vandenburgh HH, Mooney DJ.  
*Proc Natl Acad Sci U S A.* 2010 Feb 23;107(8):3287-92.  
PMID: 19966309 | PDF

**2009**

**Controlling the orientation and synaptic differentiation of myotubes with micropatterned substrates.**  
Gingras J, Rioux RM, Cuvelier D, Geisse NA, Lichtman JW, Whitesides GM, Mahadevan L, Sanes JR.  
*Biophys J*. 2009 Nov 18;97(10):2771-9.  
PMID: 19917231 | PDF

**Super-resolution laser scanning microscopy through spatiotemporal modulation.**  
Lu J, Min W, Conchello JA, Xie XS, Lichtman JW.  
*Nano Lett.* 2009 Nov;9(11):3883-9..  
PMID: 19743870 | PDF

**It’s lonely at the top: winning climbing fibers ascend dendrites solo.**  
Draft RW, Lichtman JW.  
*Neuron*. 2009 Jul 16;63(1):6-8.  
PMID: 19607787 | PDF

**Semi-automated reconstruction of neural processes from large numbers of fluorescence images.**  
Lu J, Fiala JC, Lichtman JW.  
*PLoS One.* 2009 May 21;4(5):e5655.  
PMID: 19479070 | PDF

**The interscutularis muscle connectome.**  
Lu J, Tapia JC, White OL, Lichtman JW.  
*PLoS Biol*. 2009 Feb 10;7(2):e32. doi: 10.1371/journal.pbio.1000032. Erratum in: PLoS Biol. 2009 Apr;7(4):e1000108.  
PMID: 19209956 | PDF

**2008**

**Chapter 11: Imaging fluorescent mice in vivo using confocal microscopy.**  
Turney SG, Lichtman JW.  
*Methods Cell Biol.* 2008;89:309-27.  
PMID: 19118680 | PDF

**Seeing circuits assemble.**  
Lichtman JW, Smith SJ.  
*Neuron.* 2008 Nov 6;60(3):441-8.  
PMID: 18995818 | PDF

**Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants.**  
Kerschensteiner M, Reuter MS, Lichtman JW, Misgeld T.  
*Nat Protoc.* 2008;3(10):1645-53.  
PMID: 18833201 | PDF

**Ome sweet ome: what can the genome tell us about the connectome?**  
Lichtman JW, Sanes JR.  
*Curr Opin Neurobiol.* 2008 Jun;18(3):346-53.  
PMID: 18801435 | PDF

**Lysosomal activity associated with developmental axon pruning.**  
Song JW, Misgeld T, Kang H, Knecht S, Lu J, Cao Y, Cotman SL, Bishop DL, Lichtman JW.  
*J Neurosci.* 2008 Sep 3;28(36):8993-9001.  
PMID: 18768693 | PDF

**Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo.**  
McCann CM, Tapia JC, Kim H, Coggan JS, Lichtman JW.  
*Nat Neurosci.* 2008 Jul;11(7):807-15.  
PMID: 18568021 | PDF

**A technicolour approach to the connectome.**  
Lichtman JW, Livet J, Sanes JR.  
*Nat Rev Neurosci.* 2008 Jun;9(6):417-22.  
PMID: 18446160 | PDF

**Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific.**  
Schubert T, Kerschensteiner D, Eggers ED, Misgeld T, Kerschensteiner M, Lichtman JW, Lukasiewicz PD, Wong RO.  
*J Neurophysiol.* 2008 Jul;100(1):304-16.  
PMID: 18436633 | PDF

**In vivo imaging of presynaptic terminals and postsynaptic sites in the mouse submandibular ganglion.**  
McCann CM, Lichtman JW.  
*Dev Neurobiol.* 2008 May;68(6):760-70.  
PMID: 18383540 | PDF

**2007**

**Imaging the neuromuscular junction over the past centuries.**  
Lu J, Lichtman JW.  
*Sheng Li Xue Bao.* 2007 Dec 25;59(6):683-96.  
PMID: 18157463 | PDF

**Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.**  
Livet J, Weissman TA, Kang H, Draft RW, Lu J, Bennis RA, Sanes JR, Lichtman JW.  
*Nature*. 2007 Nov 1;450(7166):56-62.  
PMID: 17972876 | PDF

**Imaging axonal transport of mitochondria in vivo.**  
Misgeld T, Kerschensteiner M, Bareyre FM, Burgess RW, Lichtman JW.  
*Nat Methods.* 2007 Jul;4(7):559-61.  
PMID: 17558414 | PDF

**Rapid synapse elimination after postsynaptic protein synthesis inhibition in vivo.**  
McCann CM, Nguyen QT, Santo Neto H, Lichtman JW.  
*J Neurosci*. 2007 May 30;27(22):6064-7.  
PMID: 17537978 | PDF

**The rise of the ‘projectome’.**  
Kasthuri N, Lichtman JW.  
*Nat Methods.* 2007 Apr;4(4):307-8. Erratum in: Nat Methods. 2007 Jul;4(7):595.  
PMID: 17396125 | PDF

**2006**

**Translational neuroscience during the Second World War.**  
Lichtman JW, Sanes JR.  
*J Exp Biol*. 2006 Sep;209(Pt 18):3485-7.  
PMID: 16943488 | PDF

**Repulsive force based snake model to segment and track neuronal axons in 3D microscopy image stacks.**  
Cai H, Xu X, Lu J, Lichtman JW, Yung SP, Wong ST.  
*Neuroimage*. 2006 Oct 1;32(4):1608-20.  
PMID: 16861006 | PDF

**2005**

**Optical sectioning microscopy.**  
Conchello JA, Lichtman JW.  
*Nat Methods.* 2005 Dec;2(12):920-31.  
PMID: 16299477 | PDF

**Fluorescence microscopy.**  
Lichtman JW, Conchello JA.  
*Nat Methods.* 2005 Dec;2(12):910-9.  
PMID: 16299476 | PDF

**A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis.**  
Schaefer AM, Sanes JR, Lichtman JW.  
*J Comp Neurol.* 2005 Sep 26;490(3):209-19.  
PMID: 16082680 | PDF

**Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter.**  
Misgeld T, Kummer TT, Lichtman JW, Sanes JR.  
*Proc Natl Acad Sci U S A*. 2005 Aug 2;102(31):11088-93.  
PMID: 16043708 | PDF

**Peptide tags for labeling membrane proteins in live cells with multiple fluorophores.**  
McCann CM, Bareyre FM, Lichtman JW, Sanes JR.  
*Biotechniques*. 2005 Jun;38(6):945-52.  
PMID: 16018556 | PDF

**In vivo imaging of axonal degeneration and regeneration in the injured spinal cord.**  
Kerschensteiner M, Schwab ME, Lichtman JW, Misgeld T.  
*Nat Med*. 2005 May;11(5):572-7.  
PMID: 15821747 | PDF

**2004**

**Axon branch removal at developing synapses by axosome shedding.**  
Bishop DL, Misgeld T, Walsh MK, Gan WB, Lichtman JW.  
*Neuron*. 2004 Nov 18;44(4):651-61.  
PMID: 15541313 | PDF

**Age-associated synapse elimination in mouse parasympathetic ganglia.**  
Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW.  
*J Neurobiol.* 2004 Aug;60(2):214-26.  
PMID: 15266652 | PDF

**Comment on “Reelin promotes peripheral synapse elimination and maturation”.**  
Bidoia C, Misgeld T, Weinzierl E, Buffelli M, Feng G, Cangiano A, Lichtman JW, Sanes JR.  
*Science*. 2004 Mar 26;303(5666):1977; author reply 1977.  
PMID: 15044788 | PDF

**Nerve-independent formation of a topologically complex postsynaptic apparatus.**  
Kummer TT, Misgeld T, Lichtman JW, Sanes JR.  
*J Cell Biol.* 2004 Mar 29;164(7):1077-87.  
PMID: 15037598 | PDF

**Structural dynamics of synapses in living animals.**  
Kasthuri N, Lichtman JW.  
*Curr Opin Neurobiol.* 2004 Feb;14(1):105-11. Erratum in: Curr Opin Neurobiol. 2004 Apr;14(2):265-6.  
PMID: 15018945 | PDF

**2003**

**Watching the neuromuscular junction.**  
Lichtman JW, Sanes JR.  
*J Neurocytol.* 2003 Jun-Sep;32(5-8):767-75.  
PMID: 15034266 | PDF

**Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo.**  
Pan YA, Misgeld T, Lichtman JW, Sanes JR.  
*J Neurosci.* 2003 Dec 10;23(36):11479-88.  
PMID: 14673013 | PDF

**LTP: perils and progress.**  
Lisman J, Lichtman JW, Sanes JR.  
*Nat Rev Neurosci*. 2003 Nov;4(11):926-9.  
PMID: 14595404 | PDF

**Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion.**  
Gan WB, Kwon E, Feng G, Sanes JR, Lichtman JW.  
*Nat Neurosci.* 2003 Sep;6(9):956-60.  
PMID: 12925856 | PDF

**Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition.**  
Buffelli M, Burgess RW, Feng G, Lobe CG, Lichtman JW, Sanes JR.  
*Nature.* 2003 Jul 24;424(6947):430-4.  
PMID: 12879071 | PDF

**The role of neuronal identity in synaptic competition.**  
Kasthuri N, Lichtman JW.  
*Nature.* 2003 Jul 24;424(6947):426-30.  
PMID: 12879070 | PDF

**Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions.**  
Grady RM, Akaaboune M, Cohen AL, Maimone MM, Lichtman JW, Sanes JR.  
*J Cell Biol.* 2003 Mar 3;160(5):741-52.  
PMID: 12604589 | PDF

**In vivo time-lapse imaging of synaptic takeover associated with naturally occurring synapse elimination.**  
Walsh MK, Lichtman JW.  
*Neuron.* 2003 Jan 9;37(1):67-73.  
PMID: 12526773 | PDF

**2002**

**Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase.**  
Misgeld T, Burgess RW, Lewis RM, Cunningham JM, Lichtman JW, Sanes JR.  
*Neuron.* 2002 Nov 14;36(4):635-48.  
PMID: 12441053 | PDF

**Pre-existing pathways promote precise projection patterns.**  
Nguyen QT, Sanes JR, Lichtman JW.  
*Nat Neurosci.* 2002 Sep;5(9):861-7.  
PMID: 12172551 | PDF

**Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands.**  
Akaaboune M, Grady RM, Turney S, Sanes JR, Lichtman JW.  
*Neuron.* 2002 Jun 13;34(6):865-76.  
PMID: 12086635 | PDF

**2001**

**Induction, assembly, maturation and maintenance of a postsynaptic apparatus.**  
Sanes JR, Lichtman JW.  
*Nat Rev Neurosci.* 2001 Nov;2(11):791-805.  
PMID: 11715056 | PDF

**The neuronal naturalist: watching neurons in their native habitat.**  
Lichtman JW, Fraser SE.  
*Nat Neurosci.* 2001 Nov;4 Suppl:1215-20.  
PMID: 11687832 | PDF

**Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice.**  
Keller-Peck CR, Walsh MK, Gan WB, Feng G, Sanes JR, Lichtman JW.  
*Neuron.* 2001 Aug 16;31(3):381-94.  
PMID: 11516396 | PDF

**Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction.**  
Keller-Peck CR, Feng G, Sanes JR, Yan Q, Lichtman JW, Snider WD.  
*J Neurosci.* 2001 Aug 15;21(16):6136-46.  
PMID: 11487637 | PDF

**Getting a bead on receptor movements.**  
Craig AM, Lichtman JW.  
*Nat Neurosci*. 2001 Mar;4(3):219-20.  
PMID: 11224530 | PDF

**2000**

**Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.**  
Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR.  
*Neuron*. 2000 Oct;28(1):41-51.  
PMID: 11086982 | PDF

**Multicolor “DiOlistic” labeling of the nervous system using lipophilic dye combinations.**  
Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW.  
*Neuron*. 2000 Aug;27(2):219-25.  
PMID: 10985343 | PDF

**Nerve terminals form but fail to mature when postsynaptic differentiation is blocked: in vivo analysis using mammalian nerve-muscle chimeras.**  
Nguyen QT, Son YJ, Sanes JR, Lichtman JW.  
*J Neurosci.* 2000 Aug 15;20(16):6077-86.  
PMID: 10934257 | PDF

**From plaque to pretzel: fold formation and acetylcholine receptor loss at the developing neuromuscular junction.**  
Marques MJ, Conchello JA, Lichtman JW.  
*J Neurosci.* 2000 May 15;20(10):3663-75.  
PMID: 10804208 | PDF

**Synapse elimination and indelible memory.**  
Lichtman JW, Colman H.  
*Neuron*. 2000 Feb;25(2):269-78..  
PMID: 10719884 | PDF

**1990-1999**

**Vital imaging and ultrastructural analysis of individual axon terminals labeled by iontophoretic application of lipophilic dye.**  
Gan WB, Bishop DL, Turney SG, Lichtman JW.  
*J Neurosci Methods.* 1999 Oct 30;93(1):13-20.  
PMID: 10598860 | PDF

**Activity-driven synapse elimination leads paradoxically to domination by inactive neurons.**  
Barber MJ, Lichtman JW.  
*J Neurosci.* 1999 Nov 15;19(22):9975-85.  
PMID: 10559405 | PDF

**Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo.**  
Akaaboune M, Culican SM, Turney SG, Lichtman JW.  
*Science*. 1999 Oct 15;286(5439):503-7.  
PMID: 10521340 | PDF

**Can molecules explain long-term potentiation?**  
Sanes JR, Lichtman JW.  
*Nat Neurosci.* 1999 Jul;2(7):597-604.  
PMID: 10404178 | PDF

**Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.**  
Burgess RW, Nguyen QT, Son YJ, Lichtman JW, Sanes JR.  
*Neuron*. 1999 May;23(1):33-44.  
PMID: 10402191 | PDF

**Axonal atrophy: the retraction reaction.**  
Bernstein M, Lichtman JW.  
*Curr Opin Neurobiol.* 1999 Jun;9(3):364-70. Review.  
PMID: 10395581 | PDF

**Development of the vertebrate neuromuscular junction.**  
Sanes JR, Lichtman JW.  
*Annu Rev Neurosci*. 1999;22:389-442.  
PMID: 10202544 | PDF

**Synaptic segregation at the developing neuromuscular junction.**  
Gan WB, Lichtman JW.  
*Science.* 1998 Nov 20;282(5393):1508-11.

PMID: 9822385 | PDF  
**Development of the neuromuscular junction: genetic analysis in mice.**  
Sanes JR, Apel ED, Burgess RW, Emerson RB, Feng G, Gautam M, Glass D, Grady RM, Krejci E, Lichtman JW, Lu JT, Massoulié J, Miner JH, Moscoso LM, Nguyen Q, Nichol M, Noakes PG, Patton BL, Son YJ, Yancopoulos GD, Zhou H.  
*J Physiol Paris.* 1998 Jun-Aug;92(3-4):167-72.  
PMID: 9789802 | PDF

**Synaptic competition during the reformation of a neuromuscular map.**  
Laskowski MB, Colman H, Nelson C, Lichtman JW.  
*J Neurosci.* 1998 Sep 15;18(18):7328-35.  
PMID: 9736653 | PDF

**Axon withdrawal during synapse elimination at the neuromuscular junction is accompanied by disassembly of the postsynaptic specialization and withdrawal of Schwann cell processes.**   
Culican SM, Nelson CC, Lichtman JW.  
*J Neurosci.* 1998 Jul 1;18(13):4953-65.  
PMID: 9634561 | PDF

**Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle.**  
Nguyen QT, Parsadanian AS, Snider WD, Lichtman JW.  
*Science*. 1998 Mar 13;279(5357):1725-9.  
PMID: 9497292 | PDF

**Alterations in synaptic strength preceding axon withdrawal.**  
Colman H, Nabekura J, Lichtman JW.  
*Science.* 1997 Jan 17;275(5298):356-61.  
PMID: 8994026 | PDF

**Are neurotrophins synaptotrophins?**  
Snider WD, Lichtman JW.  
*Mol Cell Neurosci.* 1996 Jun;7(6):433-42.  
PMID: 8875427 | PDF

**Mechanism of synapse disassembly at the developing neuromuscular junction.**  
Nguyen QT, Lichtman JW.  
*Curr Opin Neurobiol.* 1996 Feb;6(1):104-12.  
PMID: 8794054 | PDF

**A quantitative fluorescence-imaging technique for studying acetylcholine receptor turnover at neuromuscular junctions in living animals.**  
Turney SG, Culican SM, Lichtman JW.  
*J Neurosci Methods.* 1996 Feb;64(2):199-208.  
PMID: 8699881 | PDF

**Brief communication: some observations on enamel thickness and enamel prism packing in the Miocene hominoid Otavipithecus namibiensis.**  
Conroy GC, Lichtman JW, Martin LB.  
*Am J Phys Anthropol*. 1995 Dec;98(4):595-600.  
PMID: 8599388 | PDF

**Long-term synapse loss induced by focal blockade of postsynaptic receptors.**  
Balice-Gordon RJ, Lichtman JW.  
*Nature*. 1994 Dec 8;372(6506):519-24.  
PMID: 7990923 | PDF

**In vivo imaging shows loss of synaptic sites from neuromuscular junctions in a model of myasthenia gravis.**  
Rich MM, Colman H, Lichtman JW.  
*Neurology*. 1994 Nov;44(11):2138-45.  
PMID: 7969973 | PDF

**Regenerating muscle fibers induce directional sprouting from nearby nerve terminals: studies in living mice.**  
van Mier P, Lichtman JW.  
*J Neurosci.* 1994 Sep;14(9):5672-86.  
PMID: 8083762 | PDF

**Theoretical analysis of a rotating-disk partially confocal scanning microscope.**  
Conchello JA, Lichtman JW.  
*Appl Opt.* 1994 Feb 1;33(4):585-96.  
PMID: 20862053 | PDF

**Gradual loss of synaptic cartels precedes axon withdrawal at developing neuromuscular junctions.**  
Balice-Gordon RJ, Chua CK, Nelson CC, Lichtman JW.  
*Neuron.* 1993 Nov;11(5):801-15.  
PMID: 8240805 | PDF

**Interactions between nerve and muscle: synapse elimination at the developing neuromuscular junction.**  
Colman H, Lichtman JW.  
*Dev Biol.* 1993 Mar;156(1):1-10.  
PMID: 8449362 | PDF

**In vivo observations of pre- and postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions.**  
Balice-Gordon RJ, Lichtman JW.  
*J Neurosci.* 1993 Feb;13(2):834-55.  
PMID: 8426240 | PDF

**‘Cartellian’ competition at the neuromuscular junction.**  
Colman H, Lichtman JW.  
*Trends Neurosci*. 1992 Jun;15(6):197-9.  
PMID: 1378660 | PDF

**Neurobiology. From cell line to brain.**  
Sanes JR, Lichtman JW.  
*Nature*. 1992 Apr 16;356(6370):562-3.  
PMID: 1560839 | PDF

**Neuromuscular junctions shrink and expand as muscle fiber size is manipulated: in vivo observations in the androgen-sensitive bulbocavernosus muscle of mice.**  
Balice-Gordon RJ, Breedlove SM, Bernstein S, Lichtman JW.  
*J Neurosci.* 1990 Aug;10(8):2660-71.  
PMID: 2388082 | PDF

**In vivo visualization of the growth of pre- and postsynaptic elements of neuromuscular junctions in the mouse.**  
Balice-Gordon RJ, Lichtman JW.  
*J Neurosci.* 1990 Mar;10(3):894-908.  
PMID: 2156964 | PDF

**Understanding synaptic competition in theory and in practice.**  
Lichtman JW, Balice-Gordon RJ.  
*J Neurobiol.* 1990 Jan;21(1):99-106.  
PMID: 2181069 | PDF

**1989 and before**

**Motor nerve terminal loss from degenerating muscle fibers.**  
Rich M, Lichtman JW.  
*Neuron*. 1989 Dec;3(6):677-88.  
PMID: 2642014 | PDF

**High-resolution imaging of synaptic structure with a simple confocal microscope.**  
Lichtman JW, Sunderland WJ, Wilkinson RS.  
*New Biol*. 1989 Oct;1(1):75-82.  
PMID: 2488274 | PDF

**In vivo visualization of pre- and postsynaptic changes during synapse elimination in reinnervated mouse muscle.**  
Rich MM, Lichtman JW.  
*J Neurosci.* 1989 May;9(5):1781-805.  
PMID: 2542480 | PDF

**Properties of motor units in the transversus abdominis muscle of the garter snake.**  
Lichtman JW, Wilkinson RS.  
*J Physiol*. 1987 Dec;393:355-74.  
PMID: 3446800 | PDF

**Synaptic sites on reinnervated nerve cells visualized at two different times in living mice.**  
Purves D, Lichtman JW.  
*J Neurosci*. 1987 May;7(5):1492-7.  
PMID: 3572488 | PDF

**Visualization of neuromuscular junctions over periods of several months in living mice.**  
Lichtman JW, Magrassi L, Purves D.  
*J Neurosci*. 1987 Apr;7(4):1215-22.  
PMID: 3572477 | PDF

**Fluorescent probes that stain living nerve terminals.**  
Magrassi L, Purves D, Lichtman JW.  
*J Neurosci*. 1987 Apr;7(4):1207-14.  
PMID: 3572476 | PDF

**Developmental neurobiology. Trophic factor theory matures.**  
Lichtman JW, Taghert PH.  
*Nature*. 1987 Mar 26-Apr 1;326(6111):336..  
PMID: 3031503 | PDF

**Rearrangement of synapses during development.**  
Lichtman JW.  
*NIDA Res Monogr*. 1987;78:15-29.  
PMID: 3123986 | PDF

**Developmental neurobiology. Axon outgrowth in vertebrates.**  
Taghert PH, Lichtman JW.  
*Nature.* 1986 Mar 20-26;320(6059):210-11.  
PMID: 3960104 | PDF

**Regular alternation of fiber types in the transversus abdominis muscle of the garter snake.**  
Wilkinson RS, Lichtman JW.  
*J Neurosci.* 1985 Nov;5(11):2979-88.  
PMID: 2414418 | PDF

**Geometrical differences among homologous neurons in mammals.**  
Purves D, Lichtman JW.  
Science. 1985 Apr 19;228(4697):298-302.  
PMID: 3983631 | PDF

**Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes.**  
Lichtman JW, Wilkinson RS, Rich MM.  
*Nature.* 1985 Mar 28-Apr 3;314(6009):357-9.  
PMID: 3982503 | PDF

**Anatomical basis of specific connections between sensory axons and motor neurons in the brachial spinal cord of the bullfrog.**  
Lichtman JW, Jhaveri S, Frank E.  
*J Neurosci.* 1984 Jul;4(7):1754-63.  
PMID: 6610729 | PDF

**Physiological evidence for specificity of synaptic connections between individual sensory and motor neurons in the brachial spinal cord of the bullfrog.**  
Lichtman JW, Frank E.  
*J Neurosci.* 1984 Jul;4(7):1745-53.  
PMID: 6610728 | PDF

**Activity-mediated neural change.**  
Lichtman JW, Purves D.  
*Nature.* 1983 Feb 17-23;301(5901):563.  
PMID: 6828137 | PDF

**Specific connections between nerve cells.**  
Purves D, Lichtman JW.  
*Annu Rev Physiol.* 1983;45:553-65.

PMID: 6847165 | PDF  
**Elimination of synapses in the developing nervous system.**

Purves D, Lichtman JW.  
*Science.* 1980 Oct 10;210(4466):153-7.  
PMID: 7414326 | PDF

**On the predominantly single innervation of submandibular ganglion cells in the rat.**  
Lichtman JW.  
*J Physiol.* 1980 May;302:121-30.

PMID: 7411451 | PDF  
**The elimination of redundant preganglionic innervation to hamster sympathetic ganglion cells in early post-natal life.**

Lichtman JW, Purves D.  
*J Physiol.* 1980 Apr;301:213-28.  
PMID: 7411428 | PDF

**Innervation of sympathetic neurones in the guinea-pig thoracic chain.**  
Lichtman JW, Purves D, Yip JW.  
*J Physiol.* 1980 Jan;298:285-99.  
PMID: 7359403 | PDF

**On the purpose of selective innervation of guinea-pig superior cervical ganglion cells.**  
Lichtman JW, Purves D, Yip JW.  
*J Physiol.* 1979 Jul;292:69-84.  
PMID: 490406 | PDF

**Formation and maintenance of synaptic connections in autonomic ganglia.**  
*Purves D, Lichtman JW.*  
*Physiol Rev*. 1978 Oct;58(4):821-62.  
PMID: 360252 | PDF

**The reorganization of synaptic connexions in the rat submandibular ganglion during post-natal development.**  
Lichtman JW.  
*J Physiol.* 1977 Dec;273(1):155-77.  
PMID: 599418 | PDF

**Inhibition of the mitochondrial respiratory chain by alkylhydroxynaphtoquines: reversal on discharge of the energized state.**  
Howland JL, Lichtman JW, Settlemire CT.  
*Biochim Biophys Acta.* 1973 Aug 31;314(2):154-63.  
PMID: 4126990 | PDF



 

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