Saturated Reconstruction of a Volume of Neocortex

Read the original research article in Cell:

Saturated Reconstruction of a Volume of Neocortex. Kasthuri N, Hayworth KJ, Berger DR, Schalek RL, Conchello JA, Knowles-Barley S, Lee D, Vázquez-Reina A, Kaynig V, Jones TR, Roberts M, Morgan JL, Tapia JC, Seung HS, Roncal WG, Vogelstein JT, Burns R, Sussman DL, Priebe CE, Pfister H, Lichtman JW. Cell. 2015 Jul 30;162(3):648-61. [with Video Abstract

Access the dataset here:
http://www.openconnectomeproject.org/

Read Jeff Lichtman’s summary of the study on the Harvard Molecular and Cellular Biology website. 

Read the Conte Center web feature, "Imaging the Brain's Jungles: A Miniscule Yet Monumental Leap Forward"

Additional Resources:

Connectomics: Big Microscopes & Tiny Synapses. A video made for Harvard’s “Fundamentals of Neuroscience,” course, featuring Jeff Lichtman and Bobby Kasthuri.

Crumb of mouse brain reconstructed in full detail: Digital map is step towards reconstructing a whole human brain. Nature news article by Alison Abbott, with video. July 30, 2015.

From tiny slice, researchers lay bare beauty of mouse brain. Simons Foundation Autism Research Initiative (SFARI) news story by Jessica Wright. July 30, 2015.

3D brain map reveals connections between cells in nano-scale. The Guardian news piece by Helen Thomson. July 30, 2015.

These Stunning Images Will Take You On A Journey Through The Brain. Huffington Post story by Carolyn Gregoire. August 4, 2015.

BRAIN Investigators Produce Automated Technique Allowing High Resolution Reconstruction of Mouse Cortex. NIH BRAIN Initiative website. August 11, 2015.

Your brain is more complicated than you can imagine. ScienceNow video on Facebook. August 8, 2015.

lichtman_cell_2015.mp423.08 MB